Preterm birth and danger-associated molecular patterns

Adult hand lifts the foot of a premature baby

Preterm birth is the leading cause of infantile mortality. Dr Claire Kendal-Wright from the Chaminade University of Honolulu works on human extra-embryonic membranes. More specifically, she studies danger-associated molecular patterns, or DAMPs, and examines how these molecules contribute to the prelabour rupture of the membranes that leads to birth. Understanding the mechanisms involved in healthy pregnancy could eventually allow the […]

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How ubiquitin determines the fate of our proteins

How ubiquitin determines the fate of our proteins

Regulation of the multitude of protein-protein interactions that take place in the cell is essential. HECT E3 ubiquitin ligases play an important role in regulating protein functions and maintaining cellular health. However, many questions about their biological functions remain unanswered. Working at the interface of biochemistry and biophysics, Dr Donald Spratt from Clark University in Massachusetts, uses NMR spectroscopy to […]

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Seeing the structures of molecules: insights from NMR and industry

Professor Anthony Serianni's work centres around identifying the structure of molecules, which remains a key challenge within modern chemistry.

Many of the essential chemical constituents of life, including carbohydrates, are made up of complex atomic arrangements. Knowing the particular structure of a compound is important not only for identification purposes, but also for understanding how biologically relevant compounds react. Through this knowledge, their biological functions can ultimately be deciphered. Professor Anthony Serianni at the University of Notre Dame has […]

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