Systems Biology Archives

High-throughput fluorescent sequencing of biomolecules within their cellular environment

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The researchers have developed FISSEQ to sequence barcodes which can be placed in the mouse brain.

Understanding the molecular diversity within healthy or diseased tissues is crucial for the diagnosis and treatment of diseases and for gaining a better understanding of fundamental biological processes. Biological tissues contain thousands of different molecules, yet conventional staining looks at only a few at a time because it relies on a limited number of dyes. Prof George Church and Dr […]

Proteomics reveals new possibilities in the fight against infection

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The work of Dr Jennifer Geddes-McAlister at the University of Guelph investigates the interactions between hosts and pathogens to uncover new treatment options to combat infections. Her lab uses a range of techniques centered around proteomics, the study of proteins, to progress knowledge of fungal and bacterial infections in humans and agricultural crops. The results of this research can be […]

Systems biology and metabolic networks predict heterosis

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Heterosis or hybrid vigour is the improved function of a desirable quality in hybrid offspring. Predicting heterosis would mean that plant and animal breeding need not depend on time-consuming and costly field tests of numerous combinations. Dominique de Vienne, Professor at the University Paris-Saclay, France, uses metabolic networks and systems biology to study heterosis. Modelling metabolic systems has relied on […]

The mathematics of life:
Metabolic control in living cells

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Cellular metabolism is a complex network of chemical processes that convert nutrients into energy and molecules for survival. Advances in experimental and mathematical techniques are paving the way for quantitative descriptions of how metabolism regulates itself and of how it can be artificially controlled for biotechnology. Dr Diego A. Oyarzún (University of Edinburgh) uses computational models to understand metabolism, and to […]