Health & Medicine

Understanding the EGFR mutation aids the fight against lung cancer

Genetic mutations are known to be responsible for several different types of cancer. One type, known as non-small cell lung cancer, is sometimes caused by mutations in a gene called EGFR. A group of drugs called tyrosine kinase inhibitors are often used to treat patients with this type of cancer. Unfortunately, patients can develop genetic alterations, namely mutation, amplification (an […]

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Health & Medicine

Unpacking primary biliary cholangitis and its burden in Japan

Itch, fatigue, anxiety, abdominal pain. These are just some of the symptoms faced by primary biliary cholangitis (PBC) patients. The chronic autoimmune disease sees white blood cells attack bile ducts in the liver, causing bile overflow, cell damage and potentially scarring and liver failure. Although it can be successfully managed, some symptoms can linger, hampering patients’ health-related quality of life […]

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Health & Medicine

When complex systems fail: The mammalian dive response and sudden unexpected death

The mammalian dive response (MDR) conserves oxygen when a person is swimming or diving. Usually the MDR serves as a built-in safety feature of the body. Sometimes, though, the MDR interacts with other factors to cause sudden unexpected death. In particular, risk of death increases when the MDR is combined with a heart condition called long QT syndrome. In a […]

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Health & Medicine

How does age change sport performance? Master athletes have the answer

We all grow older, but the ageing process affects us differently. Many master, or veteran, athletes are examples of “successful ageing”. Their physical fitness is often recorded in sport performance records over a long period of time, making them ideal for studying the effects of ageing. Professor Emeritus Michael Stones, of Lakehead University, Ontario, Canada, used a statistical method called […]

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Health & Medicine

Serious illness decision-making: How do you plan for uncertainty?

The death toll from the current COVID-19 pandemic rises every day. Symptoms can range from a cough to severe pneumonia and acute respiratory distress syndrome. Thinking about future medical care is now more relevant than ever before. However, planning for death under conditions of certainty is not the same as planning for a serious illness, where the outcome is more […]

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Health & Medicine

Candida auris: The path of yeast resistance

Antibiotic-resistant bacteria have gained a lot of attention in recent years, but there’s another budding ‘villain’ that demands a spotlight and it comes in the form of a yeast. Candida auris debuted on the public health scene in 2009 after it was isolated from a Japanese patient’s ear canal. Since then, the multidrug-resistant fungus has become a “major healthcare threat, […]

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Health & Medicine

Tumorigenesis: Revealing cancer’s origins

Despite huge amounts of research, many aspects of cancer remain mysterious. One of these is the process of tumorigenesis – the very earliest stages of tumour development. John Evans, Emeritus Professor at the University of Otago, New Zealand, has drawn together a wealth of evidence to suggest that the extracellular matrix, the network of proteins and carbohydrates that surrounds cells, […]

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Health & Medicine

Breaking down the fort: Combatting clinical biofilms

Treating bacterial infections can be challenging, even more so when they build a fort. These forts, or ‘biofilms’, form on living and non-living surfaces, such as heart valves, and protect bacteria from immune responses and antibiotics. This can lead to serious, chronic conditions, for instance an infection of the heart’s lining (endocarditis), relapsing infections and increased mortality. To help combat […]

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Health & Medicine

Value Added Data systems: An architecture for end-user informed data preparation

As the myriad of data sources continues to grow, so does the need for cost-effective, scalable and principled techniques for integrating and cleaning big data in order to optimise the data quality and thus increase its value. Dr Norman Paton, Professor of Computer Science and Dr Nikolaos Konstantinou, a Research Fellow with the Department of Computer Science, both from the […]

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Health & Medicine

The anxiety-reducing effects of cannabidiol treatment in teenagers with social anxiety disorder

Nobuo Masataka, Professor of Primate Research Institute at Kyoto University, Japan has recently completed and published exciting research into the treatment of the debilitating condition of social anxiety disorder with cannabidiol, a constituent of cannabis. Social anxiety disorder has a major impact on sufferers and the condition is becoming increasingly prevalent. Here, Professor Masataka’s promising new research findings are presented […]

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