Health & Medicine
Raising antibodies against protein complexes
Dr John LaCava of The Rockefeller University has identified a gap in the current availability of target-specific antibodies for the analysis of intracellular protein-protein interactions. Using the latest antibody production techniques, alongside immunoprecipitation and mass spectrometry, he aims to identify important interactions between transcription factors and other macromolecules which are implicated in disease. Proteins are vital for the inner workings […]
A shining light in the fight against childhood leukaemia?
Dr C. James Lim, PhD, is an Associate Professor at the Department of Pediatrics, University of British Columbia, as well as Investigator at the Michael Cuccione Childhood Cancer Research Program at British Columbia Children’s Hospital, Vancouver, Canada. His research group aims to unravel the mechanisms underlying acquired resistance to chemotherapy in childhood malignancies, with the goal of identifying new treatment […]
Computational methods of researching cancer treatments
Artificial Intelligence (AI) and machine learning algorithms have the potential to bring substantial advances in the fields of research exploring complex diseases and trying to identify effective treatments. Dr Benjamin Haibe-Kains, working at The Princess Margaret Cancer Centre in Toronto, has spent over a decade developing machine learning tools and databases that could help scientists gain a better understanding of […]
Preventing and treating complications of heart failure and Fabry disease
Dr Gavin Y Oudit, a distinguished cardiologist from the University of Alberta, focuses his research on developing ground-breaking therapies to treat both genetic and non-genetic cardiovascular disorders, and to prevent heart failure. His exciting work into the role of ACE2 has provided a fundamental scientific understanding used in the development of therapeutic options for cardiovascular, renal and lung diseases. He […]
Unravelling the cellular mechanism of spinal muscular atrophy: from gene and modifiers to therapy
Spinal muscular atrophy (SMA) is a common neuromuscular disease characterised by weakness and wasting of muscles. People with the most severe form of the disease are unable to sit or walk and die within the first two years of life. Although the genetics of SMA are well understood, the cellular mechanisms involved are unclear and there is currently no cure. […]