Cancer immunotherapy Archives

CRISPR gene editing: Can we make cancer cells easier to kill?

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Researchers at the Gene Editing Institute have developed a CRISPR gene editing tool to disable genes causing resistance to standard care in cancer patients.

Lung cancer accounts for approximately one in five cancer deaths globally. The high death toll makes the development of new treatments and improvement of old ones a top priority. One of the challenges with traditional chemotherapy is that tumours can develop resistance to treatment. For several years, Eric B Kmiec, PhD, at the Gene Editing Institute of ChristianaCare, USA and […]

Overcoming resistance to cancer immunotherapy

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Immunotherapy, which uses the body’s own immune system to fight cancer, is a great step forward in cancer treatment. Unfortunately, however, it is currently ineffective in most patients. This resistance can be caused by a type of cell called a cancer-associated fibroblast, which builds protective defences around tumours. In a recent study, Professor Gareth Thomas and his team at the […]

Using nanoparticles for effective immune system modulation

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The development of nanoparticles is increasingly becoming an essential strategy in drug delivery. Professor Aws Alshamsan from King Saud University, Saudi Arabia, is an expert in the field of nanobiotechnology and designs drug delivery systems made of small synthetic polymers to target specific tissues with high effectiveness. These particles are internalised by the immune system, along with the drugs that […]

Reprogramming the immune system for personalised immunotherapy against cancer

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For decades, researchers have strived to understand how the immune system recognises and fights cancer, ultimately aiming to exploit and augment these processes to create more effective cancer therapies. Dr Richard Koya, Associate Professor of Oncology, Associate Director of the Center for Immunotherapy, and Director of the Vector Development & Production Facility at Roswell Park Cancer Institute is a prominent […]