neurodegenerative diseases Archives

How oxidative stress contributes to neurodegenerative diseases

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Hyslop and Chaney use biochemical and computer molecular modelling to probe interaction between H2O2 and GAPDH to identify new molecular targets for treating neurodegeneration and neurodegenerative diseases.

The human brain relies on a constant energy supply that when compromised, neurodegenerative disease ensues, initially disrupting nerve cell communication followed by nerve cell death. Paul Hyslop and Michael Chaney investigate fundamental mechanisms driving neurodegenerative disease, to identify therapeutic interventions. They focus on how an enzyme integral to energy supply to nerve cells, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) – is inhibited and […]

How does sleep affect immune-related disease risk?

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Dr Sergio Garbarino researches the links between sleep deprivation, inflammation and the immune system, and chronic diseases such as cancer and neurodegenerative diseases

Sergio Garbarino, adjunct professor in the Department of Neuroscience, Ophthalmology, Genetics, Maternal and Child Health, at the University of Genoa, Italy, is an internationally recognised sleep expert. In his recent work, he explores the interrelationships between sleep deprivation, immunity, inflammation, and chronic diseases. It is well established that sleep is essential for health. However, modern lifestyles are not conducive to […]