Tag: University at Buffalo
Improving the effectiveness of an anticancer fluoropyrimidine by molecular hybridisation
Capecitabine (Cape) – a fluoropyrimidine used primarily in the treatment of breast and colorectal cancer – disrupts the synthesis of DNA in cancer cells following its conversion to 5-fluorouracil (FU). Since FU has been associated with several potentially fatal side effects, Dr Thomas I. Kalman at the University at Buffalo and The State University of New York has developed a […]
Pioneering materials informatics: Clean technologies from molecular design
Tackling global challenges in sustainable energy production calls for the rational design of new generations of clean materials, coupling efficiency with low environmental impact. Materials discovery offers a powerful means to predict structure-property relationships in novel materials, but often lacks the ability to account for the complex interplay of length- and timescales that ultimately determine the potential of a material […]
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Cell mechanics – from bench to bedside
All cells generate and respond to mechanical forces. The role of mechanical forces in cell biology has been understudied, but the forces are essential components of our physiology in health and disease. For example, they are involved in pathologies such as cardiac arrhythmias, muscular dystrophy and metastatic cancer. Dr Frederick Sachs from the University at Buffalo, New York, focuses on […]
Patient safety and opioid medications
Hospitalised patients often require appropriate pain relief as part of their treatment. Opioids are effective medications for pain management, but can cause excessive sedation and respiratory depression resulting in patient harm. Dr Carla Jungquist of the University at Buffalo, School of Nursing, and a panel of fellow experts reviewed evidence from the past decade to provide an important update on […]