Cell mechanics – from bench to bedside

Chemical, electrical, and mechanical stimuli trigger activity in a variety of biochemical pathways.

All cells generate and respond to mechanical forces. The role of mechanical forces in cell biology has been understudied, but the forces are essential components of our physiology in health and disease. For example, they are involved in pathologies such as cardiac arrhythmias, muscular dystrophy and metastatic cancer. Dr Frederick Sachs from the University at Buffalo, New York, focuses on […]

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Cell culture protocols for growing human keratinocytes in the laboratory

Dr Hitomi Fujisaki studies human epidermal keratinocytes (skin cells).

Dr Hitomi Fujisaki, Senior Research Scientist at Nippi Research Institute of Biomatrix in Japan, studies human epidermal keratinocytes (skin cells) and cancer cells using two- and three-dimensional type I collagen substrates. Through her research, she aims to understand more about the ways in which these cells interact with the substrate that they are grown on, and how this relationship can […]

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Mitonucleons: A new chapter in the story of mitochondria?

The mitonucleon consists of multiple mitochondria.

Mitonucleons are a newly recognised type of mitochondrial superstructure. Consisting of multiple mitochondria enveloping chromatin, mitonucleons appear to be responsible for the development of unusual structures called spheroids. Dr Honoree Fleming of Castleton State College, Vermont, USA, has identified mitonucleons in human endometrial cells in vitro. Using microscopy, Dr Fleming has also observed mysterious structures called tubules, which appear to […]

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