combination therapy Archives

Drug-adapted RET mutations

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The active RET protein has been seen in many types of thyroid cancers.

RET is a protein tyrosine kinase that is upregulated and activated in many diverse forms of cancer. Treatments using RET-specific inhibitors have been highly effective, but the threat of resistance to these drugs looms. For this reason, Dr Jie Wu and Dr Blaine Mooers from the University of Oklahoma, together with Dr Vivek Subbiah from the University of Texas, decided […]

Probing Cancer: Immunotherapy and Molecular Imaging

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Dr Robins researches novel immune checkpoint inhibitor (ICI) therapies.

The Singapore-based Cancer ImmunoTherapy Imaging (CITI) programme is a Singapore-wide collaborative research group, comprising 12 research institutes. CITI’s efforts are focused on the discovery and application of peptide-based imaging probes, which target immunotherapy treatment response biomarkers. Dr Edward G Robins, Head of Radiochemistry at the Singapore Bioimaging Consortium and Deputy Director of the NUS Clinical Imaging Research Centre, alongside his […]

A new weapon to boost cancer immunotherapy

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The 4SC team monitors the expression of relevant genes in the tumours of patients before and after administration of domatinostat.

In recent years, immunooncology has paved new avenues for effective treatment across cancer types. In addition to cytotoxic chemotherapy, we can now harness the power of the human immune response against malignant cells. However, immunotherapy is not perfect, and as always, cancer has mechanisms to evade these attacks. Dr Svetlana Hamm, Head of Research and Translational Medicine at 4SC in […]

Transtympanic injections to prevent hearing loss caused by cisplatin

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Combination therapies with an otoprotectant may help to prevent hearing loss caused by chemotherapeutic agent cisplatin.

Dr Sofia Waissbluth from The Pontificia Universidad Católica de Chile is specialised in otolaryngology (conditions of the head and neck). She has reviewed clinical trials that use transtympanic injections to prevent hearing loss caused by the chemotherapeutic agent cisplatin. To date there is no ‘one-shot’ solution to protect or cure patients from hearing loss. However, combinational therapy using transtympanic injections […]