Asbestos and bile duct cancer

asbestos

Professor Giovanni Brandi and Dr Simona Tavolari, from the University of Bologna, study the association between asbestos exposure and intrahepatic cholangiocarcinoma (ICC). Case-control analyses in Italy and four Nordic countries found strong associations between occupational exposure to asbestos and ICC. Therefore, asbestos is suggested as a risk factor for ICC development. This could be due to asbestos fibres becoming trapped […]

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How real-world experience shapes clinical practice: Following one antibiotic’s journey over time

While clinical trials are vital in getting drugs to market, these tightly-controlled studies are unable to address the diverse needs of many patients in the real world. Real-world experience research can bridge the gap between clinical trials and clinical practice. Recently, Dr Mark Redell of Melinta Therapeutics, USA, introduced a collection of research experiences on the real-world use of the […]

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Understanding statistical significance of subgroups in the data science era

Understanding statistical significance of subgroups in the data science era

Statistical models are routinely used to derive inferences from large amounts of data. They directly impact several disciplines, including precision medicine and individualised learning, which rely on information concerning individuals and groups to make predictions on the expected effects of a specific intervention on population subgroups. Although it is relatively easy to find impressive-looking associations in big data, for instance […]

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