clinical trials Archives

How can diet influence women’s reproductive health?

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Dr Nicholas studies the role of energy balance and diet on reproductive function, particularly in women as they are normally underrepresented in clinical studies

The majority of clinical trials focus on male participants. Dr Dequina Nicholas, Assistant Professor at the University of California Irvine in the US, argues that there is an urgent need to focus more on women’s health, especially fertility-related complications. She is exploring the impact of what we eat on metabolism, inflammation, and reproduction, expanding the possibility that dietary manipulation can […]

Advancing imaging biomarker development and translation through the National Cancer Imaging Translational Accelerator (NCITA)

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The NCITA consortium aims to provide researchers with the infrastructure to conduct high-quality clinical research in the pursuit of standardised imaging biomarkers, and translating this into clinical settings for the early diagnosis and treatment of cancer

It is estimated that someone is diagnosed with cancer every two minutes in the UK. Clinical imaging offers a minimally invasive way of diagnosing and managing a variety of cancers. The National Cancer Imaging Translational Accelerator (NCITA) consortium now provides researchers with the infrastructure to conduct high-quality, multi-centre clinical research in the quest to develop standardised imaging biomarkers and accelerate […]

World Cancer Day 2022: Innovations in cancer research

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Despite cancer being a leading cause of death worldwide, detecting cancers early enough to treat them remains a significant challenge. World Cancer Day, held annually on February 4, presents an opportunity to celebrate the advances that have been made, and to reflect on the work still to be done. This blog post brings together five Research Outreach articles that outline […]

Asbestos and bile duct cancer

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Professor Giovanni Brandi and Dr Simona Tavolari, from the University of Bologna, study the association between asbestos exposure and intrahepatic cholangiocarcinoma (ICC). Case-control analyses in Italy and four Nordic countries found strong associations between occupational exposure to asbestos and ICC. Therefore, asbestos is suggested as a risk factor for ICC development. This could be due to asbestos fibres becoming trapped […]

How real-world experience shapes clinical practice: Following one antibiotic’s journey over time

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While clinical trials are vital in getting drugs to market, these tightly-controlled studies are unable to address the diverse needs of many patients in the real world. Real-world experience research can bridge the gap between clinical trials and clinical practice. Recently, Dr Mark Redell of Melinta Therapeutics, USA, introduced a collection of research experiences on the real-world use of the […]

Understanding statistical significance of subgroups in the data science era

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Statistical models are routinely used to derive inferences from large amounts of data. They directly impact several disciplines, including precision medicine and individualised learning, which rely on information concerning individuals and groups to make predictions on the expected effects of a specific intervention on population subgroups. Although it is relatively easy to find impressive-looking associations in big data, for instance […]